Our research is focused on understanding the mechanisms responsible for maintaining the development of healthy blood throughout an individual's lifespan, which is disrupted in various blood disorders. The laboratory investigates these mechanisms with the ultimate goal of improving blood production. Arif's lab research specifically studies hematopoiesis, examining its changes with aging and myeloid malignancies. The primary focus is on metabolic signaling that affects blood production during normal and malignant hematopoiesis, aiming to identify new players with the potential for significant impact for therapeutic purposes. The Arif lab uses a variety of approaches, such as multi-omics (Single-cell sequencing, Metabolomics, and Proteomics), Microscopy (Super-resolution imaging), and epigenetics, together with several mouse models and human cells, to address the questions below.

• Investigating the implication of mitochondria in normal, aged, and malignment hematopoiesis.
• Investigating the regulation of epigenetics that control bioenergetics in normal, aged, and malignment hematopoiesis.
• Identifying new therapeutic targets for blood disorders such as acute myeloid leukemia (AML) and Anemia.